The 2006 Brazilian Grand Prix was a Formula One motor race held on 22 October 2006 at the Autódromo José Carlos Pace, São Paulo. It was the eighteenth and final race of the 2006 FIA Formula One World Championship. The race determined the Drivers' and Constructors' Championships for the season, with Fernando Alonso and Renault winning their respective championships.

The race was won by local hero Felipe Massa, driving a Ferrari, with Alonso taking second in his Renault and Jenson Button third in a Honda. Massa was the first Brazilian driver to win his home Grand Prix since Ayrton Senna in 1993. Michael Schumacher, in what was expected to be his last race, finished fourth, having started tenth and suffered a puncture which dropped him to 19th.

This race also marked the end of the tyre war which lasted 6 years with Michelin pulling out of the sport.