The 1968 South African Grand Prix was a Formula One motor race held at Kyalami Circuit on 1 January 1968. It was race 1 of 12 in 1968 Formula One season.

The race was won by two time World Drivers' Champion and 1965 Indianapolis 500 winner Jim Clark for Lotus-Ford after starting from pole position. The race is significant as not only the last Formula One race to be won by Clark, but also the last in which he ever competed, due to his fatal crash at the Hockenheimring in Germany three months later. At this race Team Gunston became the first Formula One team to paint their cars in the livery of their sponsors instead of national colours when they entered a private Brabham for John Love and an LDS for Sam Tingle.

This was also Mike Spence's final race, as he too was killed a few months later, while practising for the 1968 Indianapolis 500.

The first six slots on the grid were filled by either previous or future world champions. However the reigning champion, Denny Hulme, only started in ninth.